Recombinant Human Interferon-stimulated gene 20 kDa protein (ISG20)

Uniprot Id

Q96AZ6

Target Species

Human

Target Name

ISG20

Target Full Name

Interferon-stimulated gene 20 kDa protein

Target Function

Interferon-induced antiviral exoribonuclease that acts on single-stranded RNA and also has minor activity towards single-stranded DNA. Exhibits antiviral activity against RNA viruses including hepatitis C virus (HCV), hepatitis A virus (HAV) and yellow fever virus (YFV) in an exonuclease-dependent manner. May also play additional roles in the maturation of snRNAs and rRNAs, and in ribosome biogenesis.

Target Subcellular Location

Nucleus. Nucleus, nucleolus. Cytoplasm. Nucleus, Cajal body.

Target Protein Families

Exonuclease superfamily

Target Tissue Specificity

Highly expressed in peripheral blood leukocytes, spleen, thymus, colon and lung. Up regulated by E2 in estrogen receptor-positive breast cancer lines.

Target Synonyms

CD25; Estrogen regulated transcript 45 protein; Estrogen-regulated transcript 45 protein; HEM45; Interferon stimulated exonuclease gene 20kDa; Interferon stimulated gene 20 kDa protein; Interferon-stimulated gene 20 kDa protein; Isg20; ISG20_HUMAN; Promyelocytic leukemia nuclear body associated protein; Promyelocytic leukemia nuclear body-associated protein ISG20

Target Background

Enables 3'-5' exonuclease activity and RNA binding activity. Involved in defense response to virus; negative regulation of viral genome replication; and nucleobase-containing compound catabolic process. Located in cytoplasm and nuclear lumen.