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Discover the potential of our Recombinant Human MMP1 protein in your developmental biology research, and broaden your understanding of its role in extracellular matrix degradation, tissue remodeling, and cell migration. MMP1, also known as interstitial collagenase, is essential for breaking down type I, II, and III collagens, thereby enabling cell movement through collagen-rich environments. Our Recombinant Human MMP1 protein offers a partial-length sequence (101-469 amino acids) to ensure maximum bioactivity and functionality. Produced in E. coli, this protein features an N-terminal 6xHis-tag, facilitating efficient purification and detection without compromising the protein's native structure or biological activity. With a purity of greater than 90% as determined by SDS-PAGE, our Recombinant Human MMP1 protein guarantees consistent and dependable results to support your research with confidence. Choose from liquid or lyophilized powder forms based on your experimental requirements.
Discover the potential of our Recombinant Human MMP1 protein in your developmental biology research, and broaden your understanding of its role in extracellular matrix degradation, tissue remodeling, and cell migration. MMP1, also known as interstitial collagenase, is essential for breaking down type I, II, and III collagens, thereby enabling cell movement through collagen-rich environments.
Our Recombinant Human MMP1 protein offers a partial-length sequence (101-469 amino acids) to ensure maximum bioactivity and functionality. Produced in E. coli, this protein features an N-terminal 6xHis-tag, facilitating efficient purification and detection without compromising the protein’s native structure or biological activity. With a purity of greater than 90% as determined by SDS-PAGE, our Recombinant Human MMP1 protein guarantees consistent and dependable results to support your research with confidence. Choose from liquid or lyophilized powder forms based on your experimental requirements.
| Cat.No | ACP02290 | Target Name | MMP1 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 101-469aa | Mol Weight | 46.5kDa |
| Protein Length | Partial | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P03956 |
|---|
Uniprot Id
P03956
Target Species
Human
Target Name
MMP1
Target Full Name
Interstitial collagenase
Target Function
Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.
Target Subcellular Location
Secreted, extracellular space, extracellular matrix.
Target Protein Families
Peptidase M10A family
Target Research Area
Developmental Biology
Target Synonyms
27 kDa interstitial collagenase; CLG; CLGN; collagenase; fibroblast; collagenase; interstitial; Fibroblast collagenase; Interstitial collagenase; Matrix metallopeptidase 1 (interstitial collagenase); Matrix metalloprotease 1; Matrix Metalloproteinase 1; Matrix metalloproteinase-1; MMP 1; MMP-1; MMP1; MMP1_HUMAN; OTTHUMP00000045866
Target Background
This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down the interstitial collagens, including types I, II, and III. The gene is part of a cluster of MMP genes on chromosome 11. Mutations in this gene are associated with chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
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