Recombinant Human Intraflagellar transport protein 88 homolog (IFT88), Truncated

Uniprot Id

Q13099

Target Species

Human

Target Name

IFT88

Target Full Name

Intraflagellar transport protein 88 homolog

Target Function

Involved in primary cilium biogenesis. Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment.

Target Subcellular Location

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Cell projection, cilium, flagellum.

Target Tissue Specificity

Expressed in the heart, brain, liver, lung, kidney, skeletal muscle and pancreas.

Target Synonyms

D13S1056E; DAF19; hTg737; Ift88; IFT88_HUMAN; Intraflagellar transport 88 homolog; Intraflagellar transport protein 88 homolog; MGC26259; Polaris homolog; Probe hTg737 (polycystic kidney disease; autosomal recessive); Recessive polycystic kidney disease protein Tg737 homolog; RP11-172H24.2; Tetratricopeptide repeat domain 10; Tetratricopeptide repeat protein 10; TG737; TPR repeat protein 10; TTC10

Target Background

This gene encodes a member of the tetratrico peptide repeat (TPR) family. The encoded protein is involved in cilium biogenesis. Mutations of a similar gene in mouse can cause polycystic kidney disease. Several transcript variants encoding distinct isoforms have been identified for this gene.