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| Cat.No | ACP18063 | Target Name | IDI1 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Expression Range | 1-227 | Protein Length | Full length protein |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q13907 |
|---|
Uniprot Id
Q13907
Target Species
Human
Target Name
IDI1
Target Full Name
Isopentenyl-diphosphate Delta-isomerase 1
Target Function
Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
Target Subcellular Location
Peroxisome.
Target Protein Families
IPP isomerase type 1 family
Target Synonyms
isopentenyl diphosphate dimethylallyl diphosphate isomerase; IDI1; IDI1_HUMAN; IPP isomerase 1; IPP isomerase; IPPI1; Isopentenyl diphosphate Delta isomerase 1; Isopentenyl diphosphate Delta isomerase; isopentenyl diphosphate dimethylallyl diphosphate isomerase 1 ; Isopentenyl pyrophosphate isomerase 1; Isopentenyl-diphosphate Delta-isomerase 1; OTTHUMP00000018951
Target Background
IDI1 encodes a peroxisomally-localized enzyme that catalyzes the interconversion of isopentenyl diphosphate (IPP) to its highly electrophilic isomer, dimethylallyl diphosphate (DMAPP), which are the substrates for the successive reaction that results in the synthesis of farnesyl diphosphate and, ultimately, cholesterol. It has been shown in peroxisomal deficiency diseases such as Zellweger syndrome and neonatal adrenoleukodystrophy that there is reduction in IPP isomerase activity.
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