Recombinant Human Isopentenyl-diphosphate Delta-isomerase 2 (IDI2)

Uniprot Id

Q9BXS1

Target Species

Human

Target Name

IDI2

Target Full Name

Isopentenyl-diphosphate delta-isomerase 2

Target Function

Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).

Target Subcellular Location

Peroxisome.

Target Protein Families

IPP isomerase type 1 family

Target Tissue Specificity

Muscle-specific expression.

Target Synonyms

IDI2; Isopentenyl-diphosphate delta-isomerase 2; EC 5.3.3.2; Isopentenyl pyrophosphate isomerase 2; IPP isomerase 2; IPPI2

Target Background

The protein encoded by this gene catalyzes the conversion of isopentenyl diphosphate to dimethylallyl diphosphate, which is a precursor for the synthesis of cholesterol and other isoprenoids. This gene, which is a product of an ancestral gene duplication event, encodes a protein that may be involved in the aggregation of alpha-synuclein in the cerebral cortex of patients with Lewy body disease. In addition, segmental copy number gains in this locus have been associated with sporadic amyotrophic lateral sclerosis.