Recombinant Human Junctophilin-4 (JPH4), Truncated

Uniprot Id

Q96JJ6

Target Species

Human

Target Name

JPH4

Target Full Name

Junctophilin-4

Target Function

Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH4 is brain-specific and appears to have an active role in certain neurons involved in motor coordination and memory.

Target Subcellular Location

Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Single-pass type IV membrane protein.

Target Protein Families

Junctophilin family

Target Synonyms

JP-4; Jph4; JPH4_HUMAN; JPHL1; Junctophilin 4; Junctophilin like 1 protein; Junctophilin-4; Junctophilin-like 1 protein; KIAA1831

Target Background

This gene encodes a member of the junctophilin family of transmembrane proteins that are involved in the formation of the junctional membrane complexes between the plasma membrane and the endoplasmic/sarcoplasmic reticulum in excitable cells. The encoded protein contains a conserved N-terminal repeat region called the membrane occupation and recognition nexus sequence that is found in other members of the junctophilin family. Alternative splicing results in multiple transcript variants.