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| Cat.No | ACP16097 | Target Name | KIRREL2 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Protein Length | Partial | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q6UWL6 |
|---|
Uniprot Id
Q6UWL6
Target Species
Human
Target Name
KIRREL2
Target Full Name
Kin of IRRE-like protein 2
Target Function
May regulate basal insulin secretion.
Target Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Target Protein Families
Immunoglobulin superfamily
Target Tissue Specificity
Highly expressed in beta-cells of the pancreatic islets.
Target Synonyms
FILTRIN ; Kin of IRRE like 2 (Drosophila); Kin of IRRE-like protein 2; Kin of irregular chiasm like 2; Kin of irregular chiasm-like protein 2; KIRR2_HUMAN; KIRREL2; NEPH3 ; Nephrin like 3; nephrin-like gene 1; Nephrin-like protein 3; NLG1
Target Background
This gene encodes a type I transmembrane protein and member of the immunoglobulin superfamily of cell adhesion molecules. The encoded protein localizes to adherens junctions in pancreatic beta cells and regulates insulin secretion. Autoantibodies against the encoded protein have been detected in serum from patients with type 1 diabetes. This gene may also play a role in glomerular development and decreased expression of this gene has been observed in human glomerular diseases. This gene and the related opposite-strand gene nephrin (GeneID: 527362) are regulated by a bidirectional promoter.
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