Recombinant Human Lens fiber major intrinsic protein (MIP), Truncated

Uniprot Id

P30301

Target Species

Human

Target Name

MIP

Target Full Name

Lens fiber major intrinsic protein

Target Function

Water channel. Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core. Plays a role in cell-to-cell adhesion and facilitates gap junction coupling.

Target Involvement

Cataract 15, multiple types (CTRCT15)

Target Subcellular Location

Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.

Target Protein Families

MIP/aquaporin (TC 1.A.8) family

Target Tissue Specificity

Expressed in the cortex and nucleus of the retina lens (at protein level). Major component of lens fiber gap junctions.

Target Research Area

Immunology

Target Synonyms

MIP; AQP0; Lens fiber major intrinsic protein; Aquaporin-0; MIP26; MP26

Target Background

Major intrinsic protein is a member of the water-transporting aquaporins as well as the original member of the MIP family of channel proteins. The function of the fiber cell membrane protein encoded by this gene is undetermined, yet this protein is speculated to play a role in intracellular communication. The MIP protein is expressed in the ocular lens and is required for correct lens function. This gene has been mapped among aquaporins AQP2, AQP5, and AQP6, in a potential gene cluster at 12q13.