Recombinant Human Leucine-rich repeat-containing protein 16C (RLTPR), Truncated

Uniprot Id

Q6F5E8

Target Species

Human

Target Name

CARMIL2

Target Full Name

Capping protein, Arp2/3 and myosin-I linker protein 2

Target Function

Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization. Plays a role in cell protrusion formations; involved in cell polarity, lamellipodial assembly, membrane ruffling and macropinosome formations. Involved as well in cell migration and invadopodia formation during wound healing. Required for CD28-mediated stimulation of NF-kappa-B signaling, involved in naive T cells activation, maturation into T memory cells, and differentiation into T helper and T regulatory cells.

Target Subcellular Location

[Isoform 2]: Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium. Cell projection, ruffle.

Target Protein Families

CARMIL family

Target Tissue Specificity

Expressed in all tissues tested, including thymus, spleen, colon, leukocytes, peripheral blood, skin, skin keratinocytes and skin fibroblasts. Strong expression is detected in naive and memory CD4+ and CD8+ T cells, naive and memory B cells, regulatory T

Target Synonyms

CARMIL2; CARMIL2b; Leucine rich repeat containing 16C; leucine-rich repeat; Leucine-rich repeat-containing protein 16C; LR16C_HUMAN; LRRC16C; RGD; RGD leucine rich repeat tropomodulin and proline rich containing protein; RGD motif leucine rich repeats tropomodulin domain and proline rich containing; Rltpr; tropomodulin and proline-rich-containing protein