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| Cat.No | ACP08346 | Target Name | LRIT3 |
|---|---|---|---|
| Target Synonyms | immunoglobulin-like domain and transmembrane domain-containing protein 3, LRIT3; Leucine-rich repeat | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q3SXY7 |
|---|
Uniprot Id
Q3SXY7
Target Species
Human
Target Name
LRIT3
Target Full Name
Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3
Target Function
Plays a role in the synapse formation and synaptic transmission between cone photoreceptor cells and retinal bipolar cells. Required for normal transmission of a light-evoked stimulus from the cone photoreceptor cells to the ON-bipolar cells and ON-ganglion cells in the inner retina. Required in retinal ON-bipolar cells for normal localization of the cation channel TRPM1 at dendrite tips. Seems to play a specific role in synaptic contacts made by ON-bipolar cells with cone photoreceptor pedicles. May also have a role in cone synapse formation. Might facilitate FGFR1 exit from the endoplasmic reticulum to the Golgi. Could be a regulator of the FGFRs
Target Involvement
Night blindness, congenital stationary, 1F (CSNB1F)
Target Subcellular Location
Cell projection, dendrite. Perikaryon. Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Target Tissue Specificity
Detected in the outer plexiform layer (OPL) of the retina where it localizes to ON-bipolar cells (at protein level).
Target Synonyms
LRIT3; Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3
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