Recombinant Human Limbic system-associated membrane protein (LSAMP)

Uniprot Id

Q13449

Target Species

Human

Target Name

LSAMP

Target Full Name

Limbic system-associated membrane protein

Target Function

Mediates selective neuronal growth and axon targeting. Contributes to the guidance of developing axons and remodeling of mature circuits in the limbic system. Essential for normal growth of the hyppocampal mossy fiber projection.

Target Subcellular Location

Cell membrane; Lipid-anchor, GPI-anchor.

Target Protein Families

Immunoglobulin superfamily, IgLON family

Target Tissue Specificity

Expressed on limbic neurons and fiber tracts as well as in single layers of the superior colliculus, spinal chord and cerebellum.

Target Synonyms

IgLON family member 3; IGLON3; Lam; LAMP; Limbic system associated membrane protein ; Limbic system associated membrane protein precursor ; Limbic system-associated membrane protein; LSAMP; LSAMP_HUMAN

Target Background

This gene encodes a member of the immunoglobulin LAMP, OBCAM and neurotrimin (IgLON) family of proteins. The encoded preproprotein is proteolytically processed to generate a neuronal surface glycoprotein. This protein may act as a selective homophilic adhesion molecule during axon guidance and neuronal growth in the developing limbic system. The encoded protein may also function as a tumor suppressor and may play a role in neuropsychiatric disorders. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed.