Recombinant Human Liprin-alpha-3 (PPFIA3), Truncated

Uniprot Id

O75145

Target Species

Human

Target Name

PPFIA3

Target Full Name

Liprin-alpha-3

Target Function

May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates.

Target Subcellular Location

Cytoplasm. Cytoplasmic vesicle, secretory vesicle, acrosome.

Target Protein Families

Liprin family, Liprin-alpha subfamily

Target Tissue Specificity

Predominantly expressed in brain. Also detected in sperm (at protein level).

Target Synonyms

LIPA3_HUMAN; liprin; Liprin-alpha-3; LPNA3; Ppfia3; Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3; protein tyrosine phosphatase; receptor type; f polypeptide (PTPRF); interacting protein (liprin); alpha 3; protein tyrosine phosphatase; receptor type; f polypeptide; alpha 3; PTPRF-interacting protein alpha-3

Target Background

The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. Liprin family protein has been shown to localize phosphatase LAR to cell focal adhesions and may be involved in the molecular organization of presynaptic active zones.