Chinese (Simplified)
English
German
Korean
Spanish
Sign up for an account to enjoy easy online shopping and instant order tracking.
The recombinant Human SSB was expressed with the amino acid range of 1-408. The calculated molecular weight for this SSB protein is 50.8 kDa. This SSB recombinant protein is manufactured in baculovirus. The N-terminal 10xHis tag and C-terminal Myc tag was fused into the coding gene segment of SSB, making it easier to detect and purify the SSB recombinant protein in the later stages of expression and purification.SSB (Lupus La protein) is involved in a wide range of research areas. It plays a crucial role in the stability and transport of RNA, especially garnering attention in the biology of small RNAs. Researchers focus on the abnormal expression of SSB in autoimmune diseases such as lupus erythematosus and its mechanisms in RNA binding and cell biology. These studies deepen researchers' understanding of SSB functions and provide new perspectives for the treatment of autoimmune diseases.
The recombinant Human SSB was expressed with the amino acid range of 1-408. The calculated molecular weight for this SSB protein is 50.8 kDa. This SSB recombinant protein is manufactured in baculovirus. The N-terminal 10xHis tag and C-terminal Myc tag was fused into the coding gene segment of SSB, making it easier to detect and purify the SSB recombinant protein in the later stages of expression and purification.SSB (Lupus La protein) is involved in a wide range of research areas. It plays a crucial role in the stability and transport of RNA, especially garnering attention in the biology of small RNAs. Researchers focus on the abnormal expression of SSB in autoimmune diseases such as lupus erythematosus and its mechanisms in RNA binding and cell biology. These studies deepen researchers’ understanding of SSB functions and provide new perspectives for the treatment of autoimmune diseases.
| Cat.No | ACP03502 | Target Name | SSB |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | Baculovirus |
| Expression Range | 1-408aa | Mol Weight | 50.8 kDa |
| Protein Length | Full length | Purity | Greater than 85% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P05455 |
|---|
Uniprot Id
P05455
Target Species
Human
Target Name
SSB
Target Full Name
Lupus La protein
Target Function
Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation. In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation.
Target Subcellular Location
Nucleus.
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
Autoantigen La; La ; La autoantigen; La autoantigen homolog; La protein; La ribonucleoprotein; La ribonucleoprotein domain family member 3; LA_HUMAN; LARP3; Lupus La antigen; Lupus La protein; Lupus La protein homolog ; MGC118101; MGC93380; mRNA for autoantigen; OTTMUSP00000014043; RP23 273G23.1; Sjoegren syndrome type B antigen; Sjogren syndrome antigen B (autoantigen La); Sjogren syndrome antigen B; SS B; SS-B; SS-B/La protein ; SSB
Target Background
The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Alternative promoter usage results in two different transcript variants which encode the same protein.
Free shipping on orders $999+
Advenit post multos Scudilo Scutariorum tribunus velament
We accept credit cards, PayPal, and bank wires
Responsive and knowledgable customer service via email, text or phone
Notification
