Recombinant Human Mediator of RNA polymerase II transcription subunit 25 (MED25)

Cat.No	ACP16502	Target Name	MED25
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Expression Range	1-747	Protein Length	Full length protein
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP16502

Target Name

MED25

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Expression Range

1-747

Protein Length

Full length protein

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q71SY5

Background Information

Uniprot Id

Q71SY5
Target Species

Human
Target Name

MED25
Target Full Name

Mediator of RNA polymerase II transcription subunit 25
Target Function

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for RARA/RXRA-mediated transcription.
Target Involvement

Charcot-Marie-Tooth disease 2B2 (CMT2B2); Basel-Vanagaite-Smirin-Yosef syndrome (BVSYS)
Target Subcellular Location

Nucleus.
Target Protein Families

Mediator complex subunit 25 family
Target Tissue Specificity

Ubiquitously expressed. Highest levels in brain, heart, kidney, peripheral leukocytes, placenta, skeletal muscle and spleen.
Target Synonyms

ACID1; Activator interaction domain 1 protein; Activator interaction domain-containing protein 1; Activator-recruited cofactor 92 kDa component; ARC/mediator transcriptional coactivator subunit ; ARC/mediator transcriptional coactivator subunit ARC92; ARC92; BVSYS; CMT2B2; DKFZp434K0512; FLJ10193; med25; MED25 protein; MED25_HUMAN; Mediator complex subunit 25; Mediator of RNA polymerase II transcription subunit 25; Mediator of RNA polymerase II transcription; subunit 25 homolog (S cerevisiae); Mediator of RNA polymerase II transcription; subunit 25 homolog (yeast); MGC70671; p78; prostate-derived protein 78 kDa; PTOV2; TCBAP0758
Target Background

This gene encodes a component of the transcriptional coactivator complex termed the Mediator complex. This complex is required for transcription of most RNA polymerase II-dependent genes. The encoded protein plays a role in chromatin modification and in preinitiation complex assembly. Mutations in this gene are associated with Charcot-Marie-Tooth disease type 2B2.

Recombinant Human Mediator of RNA polymerase II transcription subunit 25 (MED25)

Specifications

Immunogen Information

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