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| Cat.No | ACP00769 | Target Name | SPO11 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 1-396aa | Mol Weight | 51.4 kDa |
| Protein Length | Full length | Purity | Greater than 85% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9Y5K1 |
|---|
Uniprot Id
Q9Y5K1
Target Species
Human
Target Name
SPO11
Target Full Name
Meiotic recombination protein SPO11
Target Function
Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with TOP6BL, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles. Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2.
Target Subcellular Location
Nucleus.
Target Protein Families
TOP6A family
Target Tissue Specificity
Highly expressed in testis.
Target Research Area
Cancer
Target Synonyms
Cancer/testis antigen 35; CT35; Meiotic recombination protein SPO 11; Meiotic recombination protein SPO11; MGC39953; SPATA43; Spermatogenesis associated 43; SPO 11; SPO11; SPO11 meiotic protein covalently bound to DSB; SPO11 meiotic protein covalently bound to DSB homolog; SPO11 meiotic protein covalently bound to DSB like; SPO11_HUMAN; TOPVIA
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