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| Cat.No | ACP19950 | Target Name | TRABD2B |
|---|---|---|---|
| Target Synonyms | TRABD2B; HKAT; TIKI2; Metalloprotease TIKI2; EC 3.4.-.-; Heart; kidney and adipose-enriched transmembrane protein homolog; TRAB domain-containing protein 2B | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | A6NFA1 |
|---|
Uniprot Id
A6NFA1
Target Species
Human
Target Name
TRABD2B
Target Full Name
Metalloprotease TIKI2
Target Function
Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation.
Target Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Target Protein Families
TIKI family
Target Synonyms
TRABD2B; HKAT; TIKI2; Metalloprotease TIKI2; EC 3.4.-.-; Heart; kidney and adipose-enriched transmembrane protein homolog; TRAB domain-containing protein 2B
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