Recombinant Human Mitochondrial sodium/hydrogen exchanger 9B2 (SLC9B2), Truncated

Uniprot Id

Q86UD5

Target Species

Human

Target Name

SLC9B2

Target Full Name

Sodium/hydrogen exchanger 9B2

Target Function

Na(+)/H(+) antiporter that extrudes Na(+) or Li(+) in exchange for external protons across the membrane. Contributes to the regulation of intracellular pH, sodium homeostasis, and cell volume. Plays an important role for insulin secretion and clathrin-mediated endocytosis in beta-cells. Involved in sperm motility and fertility. It is controversial whether SLC9B2 plays a role in osteoclast differentiation or not.

Target Subcellular Location

Cell membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. Cell projection, cilium, flagellum membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein.

Target Protein Families

Monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family

Target Tissue Specificity

Widely expressed. High levels detected in the distal tubules of the kidney nephron. Detected in red blood cells (at protein level).

Target Synonyms

SLC9B2; NHA2; NHEDC2; Sodium/hydrogen exchanger 9B2; Na(+)/H(+) exchanger NHA2; Na(+)/H(+) exchanger-like domain-containing protein 2; NHE domain-containing protein 2; Sodium/hydrogen exchanger-like domain-containing protein 2; Solute carrier family 9 subfamily B member 2