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Recombinant Human Muscleblind-like protein 3 (MBNL3)

ACP11731

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Specifications

Cat.No	ACP11731	Target Name	MBNL3
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Expression Range	1-354	Protein Length	Full length protein
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q9NUK0

Background Information

Uniprot Id

Q9NUK0
Target Species

Human
Target Name

MBNL3
Target Full Name

Muscleblind-like protein 3
Target Function

Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. May play a role in myotonic dystrophy pathophysiology (DM). Could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction.
Target Subcellular Location

Nucleus. Cytoplasm. Note=Greater concentration in the nucleus. In both DM1 and DM2 patients, colocalizes with nuclear foci of retained expanded-repeat transcripts.
Target Protein Families

Muscleblind family
Target Tissue Specificity

Highly expressed in the placenta.
Target Synonyms

A530038J18Rik; AI661274; CHCR; Cys3His CCG1 required protein; Cys3His CCG1-required protein; E430034C16Rik; MBLX; MBLX39; MBNL 3; Mbnl3; MBNL3_HUMAN; MBXL; Muscleblind like 3; Muscleblind like protein 3; Muscleblind like splicing regulator 3; Muscleblind like X linked protein; Muscleblind-like protein 3; Muscleblind-like X-linked protein; OTTMUSP00000019072; OTTMUSP00000019073; OTTMUSP00000019074; Protein HCHCR; RP23-98P13.1

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Recombinant Human Muscleblind-like protein 3 (MBNL3)

Specifications

Immunogen Information

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