Recombinant Human?Myb-related?protein?A (MYBL1)

Uniprot Id

P10243

Target Species

Human

Target Name

MYBL1

Target Full Name

Myb-related protein A

Target Function

Transcription factor that specifically recognizes the sequence 5'-YAAC[GT]G-3'. Acts as a master regulator of male meiosis by promoting expression of piRNAs: activates expression of both piRNA precursor RNAs and expression of protein-coding genes involved in piRNA metabolism. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity. Transcriptional activator of SOX30.

Target Subcellular Location

Nucleus.

Target Tissue Specificity

Expressed in a variety of lymphoid and solid tumor lines cultured in vitro.

Target Research Area

Epigenetics and Nuclear Signaling

Target Synonyms

A-Myb; AMYB; MGC120059; MGC120061; Myb related protein A; Myb-like protein 1; Myb-related protein A; MYBA_HUMAN; MYBL1

Target Background

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleoplasm.