Recombinant Human MYC-induced nuclear antigen (MINA)

Uniprot Id

Q8IUF8

Target Species

Human

Target Name

RIOX2

Target Full Name

Ribosomal oxygenase 2

Target Function

Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles.

Target Subcellular Location

Nucleus. Nucleus, nucleolus.

Target Protein Families

ROX family, MINA53 subfamily

Target Tissue Specificity

Expressed in liver, skeletal muscle, heart, pancreas, and placenta. Not detected in brain, lung or kidney. Expressed in several lung cancer tissues, but is barely detected in the adjacent non-cancerous tissues. Also highly expressed in several esophageal

Target Synonyms

60S ribosomal protein L27a histidine hydroxylase; Bifunctional lysine specific demethylase and histidyl hydroxylase MINA; FLJ14393; Histone lysine demethylase MINA; MDIG; MINA; MINA_HUMAN; Mineral dust-induced gene protein; Myc induced nuclear antigen 53 kDa; MYC induced nuclear antigen; MYC-induced nuclear antigen; NO52; Nucleolar protein 52; Ribosomal oxygenase MINA; ROX

Target Background

MINA is a c-Myc (MYC; MIM 190080) target gene that may play a role in cell proliferation or regulation of cell growth. (Tsuneoka et al., 2002 [PubMed 12091391]; Zhang et al., 2005 [PubMed 15897898]).