Home Products Recombinant Human Myeloma-overexpressed gene 2 protein (MYEOV2)

Recombinant Human Myeloma-overexpressed gene 2 protein (MYEOV2)

ACP12703

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Specifications

Cat.No	ACP12703	Target Name	COPS9
Target Synonyms	COPS9; MYEOV2; COP9 signalosome complex subunit 9; CSN acidic protein; CSNAP; Myeloma-overexpressed gene 2 protein	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	1-57
Protein Length	Full length protein	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q8WXC6

Background Information

Uniprot Id

Q8WXC6
Target Species

Human
Target Name

COPS9
Target Full Name

COP9 signalosome complex subunit 9
Target Function

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Plays a role in cell proliferation.; Negatively regulates neddylation of proteins, including ribosoaml protein RPL11
Target Subcellular Location

[Isoform 1]: Nucleus. Cytoplasm. Nucleus, nucleoplasm.; [Isoform 2]: Nucleus, nucleoplasm.
Target Protein Families

CSN9 family
Target Synonyms

COPS9; MYEOV2; COP9 signalosome complex subunit 9; CSN acidic protein; CSNAP; Myeloma-overexpressed gene 2 protein

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Recombinant Human Myeloma-overexpressed gene 2 protein (MYEOV2)

Specifications

Immunogen Information

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