Recombinant Human Myosin-7B (MYH7B), Truncated

Uniprot Id

A7E2Y1

Target Species

Human

Target Name

MYH7B

Target Full Name

Myosin-7B

Target Function

Involved in muscle contraction.

Target Subcellular Location

Membrane; Peripheral membrane protein.

Target Protein Families

TRAFAC class myosin-kinesin ATPase superfamily, Myosin family

Target Tissue Specificity

Expressed in heart, skeletal muscle, testis, and all specific brain regions examined. Slightly lower expression was detected in ovary and kidney, and intermediate expression was detected in lung, pancreas, spleen and liver.

Target Synonyms

Antigen MLAA-21; cardiac muscle beta isoform; Myh7b; MYH7B_HUMAN; Myosin cardiac muscle beta chain; Myosin heavy chain 7B; Myosin-7B; Slow A MYH14

Target Background

The myosin II molecule is a multi-subunit complex consisting of two heavy chains and four light chains. This gene encodes a heavy chain of myosin II, which is a member of the motor-domain superfamily. The heavy chain includes a globular motor domain, which catalyzes ATP hydrolysis and interacts with actin, and a tail domain in which heptad repeat sequences promote dimerization by interacting to form a rod-like alpha-helical coiled coil. This heavy chain subunit is a slow-twitch myosin. Alternatively spliced transcript variants have been found, but the full-length nature of these variants is not determined.