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Recombinant Human Myosin regulatory light chain 12B (MYL12B)

ACP00979

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Specifications

Cat.No	ACP00979	Target Name	MYL12B
Form	Liquid or Lyophilized powder	Expression System	E.coli
Expression Range	1-172aa	Mol Weight	51.3 kDa
Protein Length	Full length	Purity	Greater than 85% as determined by SDS-PAGE.
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	O14950

Background Information

Uniprot Id

O14950
Target Species

Human
Target Name

MYL12B
Target Full Name

Myosin regulatory light chain 12B
Target Function

Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion.
Target Tissue Specificity

Ubiquitously expressed in various hematopoietic cells.
Target Research Area

Others
Target Synonyms

ML12B_HUMAN; MLC 2A; MLC-2; MLC-2a; MLC-B; MLC20; MRLC2; MYL12B; MYLC2B; Myosin light chain 12B regulatory; Myosin regulatory light chain 12B; myosin regulatory light chain 2; Myosin regulatory light chain 2-B; myosin regulatory light chain 2-B; smooth muscle isoform; Myosin regulatory light chain 20 kDa; Myosin regulatory light chain MRLC2; myosin; light chain 12B; regulatory; OTTHUMP00000162244; OTTHUMP00000165806; OTTHUMP00000165807; OTTHUMP00000165808; SHUJUN-1; smooth muscle isoform
Target Background

The activity of nonmuscle myosin II (see MYH9; MIM 160775) is regulated by phosphorylation of a regulatory light chain, such as MRLC2. This phosphorylation results in higher MgATPase activity and the assembly of myosin II filaments (Iwasaki et al., 2001 [PubMed 11942626]).

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Recombinant Human Myosin regulatory light chain 12B (MYL12B)

Specifications

Immunogen Information

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