Recombinant Human N-acetylserotonin O-methyltransferase-like protein (ASMTL)

Uniprot Id

O95671

Target Species

Human

Target Name

ASMTL

Target Full Name

Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein

Target Function

Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. Can also hydrolyze CTP and the modified nucleotides pseudo-UTP, 5-methyl-UTP (m(5)UTP) and 5-methyl-CTP (m(5)CTP). Has weak activity with dCTP, 8-oxo-GTP and N(4)-methyl-dCTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. In addition, the presence of the putative catalytic domain of S-adenosyl-L-methionine binding in the C-terminal region argues for a methyltransferase activity (Probable).

Target Protein Families

Class I-like SAM-binding methyltransferase superfamily, Cation-independent O-methyltransferase family; Maf family

Target Tissue Specificity

Widely expressed. In adult, highly expressed in pancreas, placenta, fibroblast, thymus, prostate, testis, ovary and colon. Expressed at lower levels in spleen, small intestine and leukocytes. In fetus, expressed at high levels in the lung and kidney and a

Target Synonyms

Acetylserotonin N methyltransferase like; Acetylserotonin O methyltransferase like; ASML_HUMAN; ASMTL; ASMTLX; ASMTLY; ASTML; N acetylserotonin O methyltransferase like protein; N-acetylserotonin O-methyltransferase-like protein

Target Background

The protein encoded by this gene has an N-terminus that is similar to the multicopy associated filamentation (maf) protein of Bacillus subtilis and to orfE of Escherichia coli, while the C-terminus is similar to N-acetylserotonin O-methyltransferase. This gene is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. Three transcript variants encoding different isoforms have been found for this gene.