Recombinant Human N6-adenosine-methyltransferase non-catalytic subunit (METTL14)

Cat.No	ACP00507	Target Name	METTL14
Target Synonyms	Methyltransferase-like protein 14;hMETTL14	Form	Liquid or Lyophilized powder
Expression System	E.coli	Expression Range	1-456aa
Mol Weight	59.2 kDa	Protein Length	Full length
Purity	Greater than 85% as determined by SDS-PAGE.	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP00507

Target Name

METTL14

Target Synonyms

Methyltransferase-like protein 14;hMETTL14

Form

Liquid or Lyophilized powder

Expression System

E.coli

Expression Range

1-456aa

Mol Weight

59.2 kDa

Protein Length

Full length

Purity

Greater than 85% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q9HCE5

Background Information

Uniprot Id

Q9HCE5
Target Species

Human
Target Name

METTL14
Target Full Name

N(6)-adenosine-methyltransferase non-catalytic subunit METTL14
Target Function

The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing. M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation. In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization. M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis. M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells.
Target Subcellular Location

Nucleus.
Target Protein Families

MT-A70-like family
Target Research Area

Cell Biology
Target Synonyms

KIAA1627; MET14_HUMAN; Methyltransferase like 14; Methyltransferase-like protein 14; METTL14; N6-adenosine-methyltransferase subunit METTL14; OTTHUMP00000219837
Target Background

Enables mRNA binding activity. Contributes to mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity. Involved in mRNA metabolic process; negative regulation of hematopoietic progenitor cell differentiation; and positive regulation of translation. Located in nucleoplasm. Part of RNA N6-methyladenosine methyltransferase complex.

Recombinant Human N6-adenosine-methyltransferase non-catalytic subunit (METTL14)

Specifications

Immunogen Information

Inquire Recombinant Human N6-adenosine-methyltransferase non-catalytic subunit (METTL14) Now

Related Products