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| Cat.No | ACP10816 | Target Name | NDOR1 |
|---|---|---|---|
| Target Synonyms | NDOR1; NR1; NADPH-dependent diflavin oxidoreductase 1; EC 1.18.1.-; NADPH-dependent FMN and FAD-containing oxidoreductase; Novel reductase 1 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-597 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9UHB4 |
|---|
Uniprot Id
Q9UHB4
Target Species
Human
Target Name
NDOR1
Target Full Name
NADPH-dependent diflavin oxidoreductase 1
Target Function
NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of CIAPIN1, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. It can also reduce the [2Fe-2S] cluster of CISD1 and activate this protein implicated in Fe/S cluster repair. In vitro can fully activate methionine synthase/MTR in the presence of soluble cytochrome b5/CYB5A.
Target Subcellular Location
Cytoplasm, perinuclear region.
Target Protein Families
NADPH-dependent diflavin oxidoreductase NDOR1 family; Flavodoxin family; Flavoprotein pyridine nucleotide cytochrome reductase family
Target Tissue Specificity
Low expression in brain, heart, kidney, pancreas, prostate and skeletal muscle. Highest levels in the placenta. Expressed in cancer cell lines including promyelocytic leukemia, HeLaS3, chronic myelagenous leukemia, lymphoblastic leukemia, Burkitt's lympho
Target Synonyms
NDOR1; NR1; NADPH-dependent diflavin oxidoreductase 1; EC 1.18.1.-; NADPH-dependent FMN and FAD-containing oxidoreductase; Novel reductase 1
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