Recombinant Human Nanos homolog 2 (NANOS2)

Uniprot Id

P60321

Target Species

Human

Target Name

NANOS2

Target Full Name

Nanos homolog 2

Target Function

Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for the maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for the maintenance of their normal state.

Target Subcellular Location

Cytoplasm. Cytoplasm, P-body. Cytoplasm, perinuclear region.

Target Protein Families

Nanos family

Target Tissue Specificity

Testis and ovary. Expression found in several spermatogenic stages: in cells on the periphery of the tubules which could correspond to spermatogonia, in spermatocytes and in round spermatids (at protein level).

Target Research Area

Epigenetics and Nuclear Signaling

Target Synonyms

NANO2_HUMAN; Nanos homolog 2; Nanos homolog 2 Drosophila; NANOS2; NOS-2; NOS2