Recombinant Human Netrin-4 (NTN4)

Uniprot Id

Q9HB63

Target Species

Human

Target Name

NTN4

Target Full Name

Netrin-4

Target Function

May play an important role in neural, kidney and vascular development. Promotes neurite elongation from olfactory bulb explants.

Target Subcellular Location

Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.

Target Tissue Specificity

Expressed in kidney, spleen, mammary gland, aorta, heart, ovary, prostate and fetal spleen.

Target Research Area

Neuroscience

Target Synonyms

Beta netrin; Beta-netrin; FLJ23180; Hepar derived netrin like protein; Hepar-derived netrin-like protein; NET4_HUMAN; Netrin-4; Netrin4; NTN 4; NTN4; PRO3091

Target Background

This gene encodes a member of the netrin family of proteins, which function in various biological processes including axon guidance, tumorogenesis, and angiogenesis. Netrins are laminin-related proteins that have an N-terminal laminin-type domain, epidermal growth factor-like repeat domain, and a positively charged heparin-binding domain at the C-terminus. The protein encoded by this gene is involved in processes including neurite growth and migration, angiogenesis and mural cell adhesion to endothelial cells. Alternative splicing results in multiple transcript variants.