Recombinant Human Neutrophil collagenase (MMP8)

Uniprot Id

P22894

Target Species

Human

Target Name

MMP8

Target Full Name

Neutrophil collagenase

Target Function

Can degrade fibrillar type I, II, and III collagens.

Target Subcellular Location

Cytoplasmic granule. Secreted, extracellular space, extracellular matrix. Note=Stored in intracellular granules.

Target Protein Families

Peptidase M10A family

Target Tissue Specificity

Neutrophils.

Target Research Area

Cancer

Target Synonyms

CLG 1; CLG1; Collagenase 1; Collagenase 1 neutrophil; HNC; Matrix metallopeptidase 8 (neutrophil collagenase); Matrix metalloprotease 8; Matrix metalloproteinase-8; MMP 8; MMP-8; Mmp8; MMP8_HUMAN; Neutrophil collagenase; PMNL CL; PMNL collagenase; PMNL-CL; PMNLCL

Target Background

This gene encodes a member of the matrix metalloproteinase (MMP) family of proteins. These proteins are involved in the breakdown of extracellular matrix in embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Proteolysis at different sites on this protein results in multiple active forms of the enzyme with distinct N-termini. This protein functions in the degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants.