Home Products Uncategorized Recombinant Human Nitric oxide synthase-interacting protein (NOSIP)

Recombinant Human Nitric oxide synthase-interacting protein (NOSIP)

ACP09506

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Specifications

Cat.No	ACP09506	Target Name	NOSIP
Target Synonyms	NOSIP; CGI-25; Nitric oxide synthase-interacting protein; E3 ubiquitin-protein ligase NOSIP; EC 2.3.2.27; RING-type E3 ubiquitin transferase NOSIP; eNOS-interacting protein	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	1-301
Protein Length	Full length protein	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q9Y314

Background Information

Uniprot Id

Q9Y314
Target Species

Human
Target Name

NOSIP
Target Full Name

Nitric oxide synthase-interacting protein
Target Function

E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB. Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity.
Target Subcellular Location

Cytoplasm. Nucleus. Note=Translocates from nucleus to cytoplasm in the G2 phase of the cell cycle (PubMed:16135813).
Target Protein Families

NOSIP family
Target Tissue Specificity

Expressed in heart, brain and lung. Present in endothelial cells (at protein level).
Target Synonyms

NOSIP; CGI-25; Nitric oxide synthase-interacting protein; E3 ubiquitin-protein ligase NOSIP; EC 2.3.2.27; RING-type E3 ubiquitin transferase NOSIP; eNOS-interacting protein
Target Background

The protein encoded by this gene may modulate the activity and localization of nitric oxide synthase (endothelial and neuronal) and thus nitric oxide production. Alternative splicing results in multiple transcript variants that encode the same protein.

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Recombinant Human Nitric oxide synthase-interacting protein (NOSIP)

Specifications

Immunogen Information

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