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The expression vector recombined with the recombinant DNA was transformed into the E.coli for expression. The recombinant DNA resulted from the fusion of the gene coding for the 556-871aa of the human TYK2 protein and the N-terminal 10xHis tag and C-terminal Myc tag gene. The product was purified and isolated to get the recombinant human TYK2 protein with N-terminal 10xHis tag and C-terminal Myc tag. This recombinant TYK2 protein's purity reaches up to 85%.TYK2 is a gene encoding an enzyme named non-receptor tyrosine-protein kinase TYK2 (abbreviated TYK2) and belongs to protein kinase superfamily or tyr protein kinase family. This protein is observed in all cell lines analyzed and expressed in a variety of lymphoid and non-lymphoid cell lines. This enzyme can transfer the phosphate group from ATP to a tyrosine residue of a protein (phosphorylation). It plays a key role in many cellular functions by switching on or switching off other enzymes in a cell as a regulator. Disease associated with TYK2 includes immunodeficiency 35. This protein is probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling.
The expression vector recombined with the recombinant DNA was transformed into the E.coli for expression. The recombinant DNA resulted from the fusion of the gene coding for the 556-871aa of the human TYK2 protein and the N-terminal 10xHis tag and C-terminal Myc tag gene. The product was purified and isolated to get the recombinant human TYK2 protein with N-terminal 10xHis tag and C-terminal Myc tag. This recombinant TYK2 protein’s purity reaches up to 85%.TYK2 is a gene encoding an enzyme named non-receptor tyrosine-protein kinase TYK2 (abbreviated TYK2) and belongs to protein kinase superfamily or tyr protein kinase family. This protein is observed in all cell lines analyzed and expressed in a variety of lymphoid and non-lymphoid cell lines. This enzyme can transfer the phosphate group from ATP to a tyrosine residue of a protein (phosphorylation). It plays a key role in many cellular functions by switching on or switching off other enzymes in a cell as a regulator. Disease associated with TYK2 includes immunodeficiency 35. This protein is probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling.
| Cat.No | ACP05182 | Target Name | TYK2 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 556-871aa | Mol Weight | 42.6 kDa |
| Protein Length | Partial | Purity | Greater than 85% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P29597 |
|---|
Uniprot Id
P29597
Target Species
Human
Target Name
TYK2
Target Full Name
Non-receptor tyrosine-protein kinase TYK2
Target Function
Non-receptor kinase involved in various processes including cell growth, development, cell migration, innate and adaptive immunity. Plays both structural and catalytic roles in numerous cytokines and interferons signaling. Associates with cytokine and growth factor receptors and activate STAT family members including STAT1, STAT3, STAT4 or STAT6. The heterodimeric cytokine receptor complexes are composed of a TYK2-associated receptor chain (IFNAR1, IL12RB1, IL10RB or IL13RA1) which serves as the signal transducing chain harboring STAT docking sites once phosphorylated by TYK2, and a second receptor chain associated either with JAK1 or JAK2. In turn, recruited STATs are phosphorylated, form homo- and heterodimers, translocate to the nucleus, and regulate cytokine/growth factor responsive genes. Negatively regulates STAT3 activity by promototing phosphorylation at a specific tyrosine that differs from the site used for signaling.
Target Involvement
Immunodeficiency 35 (IMD35)
Target Protein Families
Protein kinase superfamily, Tyr protein kinase family, JAK subfamily
Target Tissue Specificity
Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines.
Target Research Area
Signal Transduction
Target Synonyms
JTK 1; JTK1; Non receptor tyrosine protein kinase 2; Non receptor tyrosine protein kinase TYK2; Non-receptor tyrosine-protein kinase TYK2; OTTHUMP00000232745; OTTHUMP00000232746; OTTHUMP00000232748; Protein Tyrosine Kinase 2; TYK 2; Tyk2; TYK2_HUMAN; Tyrosine kinase 2
Target Background
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also a component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with Immunodeficiency 35.
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