Recombinant Human Nucleoside diphosphate-linked moiety X motif 6 (NUDT6)

Uniprot Id

P53370

Target Species

Human

Target Name

NUDT6

Target Full Name

Nucleoside diphosphate-linked moiety X motif 6

Target Function

May contribute to the regulation of cell proliferation.

Target Subcellular Location

Cytoplasm. Nucleus. Mitochondrion. Note=Subcellular location may vary between isoforms.

Target Protein Families

Nudix hydrolase family

Target Tissue Specificity

Detected in liver, kidney and esophagus (at protein level). Ubiquitous.

Target Synonyms

NUDT6; FGF2AS; Nucleoside diphosphate-linked moiety X motif 6; Nudix motif 6; EC 3.6.1.-; Antisense basic fibroblast growth factor; Protein GFG

Target Background

This gene overlaps and lies on the opposite strand from FGF2 gene, and is thought to be the FGF2 antisense gene. The two genes are independently transcribed, and their expression shows an inverse relationship, suggesting that this antisense transcript may regulate FGF2 expression. This gene has also been shown to have hormone-regulatory and antiproliferative actions in the pituitary that are independent of FGF2 expression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.