Recombinant Human Nucleotide triphosphate diphosphatase NUDT15 (NUDT15)

Cat.No	ACP10562	Target Name	NUDT15
Target Synonyms	8-dihydro-8-oxoguanine triphosphatase NUDT15; RP11-90M2.1	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	1-164
Protein Length	Full length protein	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP10562

Target Name

NUDT15

Target Synonyms

8-dihydro-8-oxoguanine triphosphatase NUDT15; RP11-90M2.1

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Expression Range

1-164

Protein Length

Full length protein

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q9NV35

Background Information

Uniprot Id

Q9NV35
Target Species

Human
Target Name

NUDT15
Target Full Name

Nucleotide triphosphate diphosphatase NUDT15
Target Function

May catalyze the hydrolysis of nucleoside triphosphates including dGTP, dTTP, dCTP, their oxidized forms like 8-oxo-dGTP and the prodrug thiopurine derivatives 6-thio-dGTP and 6-thio-GTP. Could also catalyze the hydrolysis of some nucleoside diphosphate derivatives. Hydrolyzes oxidized nucleosides triphosphates like 8-oxo-dGTP in vitro, but the specificity and efficiency towards these substrates are low. Therefore, the potential in vivo sanitizing role of this enzyme, that would consist in removing oxidatively damaged forms of nucleosides to prevent their incorporation into DNA, is unclear. Through the hydrolysis of thioguanosine triphosphates may participate in the catabolism of thiopurine drugs. May also have a role in DNA synthesis and cell cycle progression by stabilizing PCNA. Exhibits decapping activity towards dpCoA-capped RNAs in vitro.
Target Protein Families

Nudix hydrolase family
Target Synonyms

8-dihydro-8-oxoguanine triphosphatase NUDT15; 8-oxo-dGTPase NUDT15; A730068G11Rik; EC 3.1.6.-; FLJ10956; MGC104352; MTH2; MutT homolog 2; Nucleoside diphosphate-linked moiety X motif 15; NUD15_HUMAN; Nudix (nucleoside diphosphate linked moiety X)-type motif ; Nudix motif 15; NUDT15; OTTHUMP00000018389; Probable 7; Probable 7,8-dihydro-8-oxoguanine triphosphatase NUDT15; RP11-90M2.1
Target Background

This gene encodes an enzyme that belongs to the Nudix hydrolase superfamily. Members of this superfamily catalyze the hydrolysis of nucleoside diphosphates, including substrates like 8-oxo-dGTP, which are a result of oxidative damage, and can induce base mispairing during DNA replication, causing transversions. The encoded enzyme is a negative regulator of thiopurine activation and toxicity. Mutations in this gene result in poor metabolism of thiopurines, and are associated with thiopurine-induced early leukopenia. Multiple pseudogenes of this gene have been identified.

Recombinant Human Nucleotide triphosphate diphosphatase NUDT15 (NUDT15)

Specifications

Immunogen Information

Inquire Recombinant Human Nucleotide triphosphate diphosphatase NUDT15 (NUDT15) Now

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