Recombinant Human Oxidative stress-induced growth inhibitor 1 (OSGIN1)

Uniprot Id

Q9UJX0

Target Species

Human

Target Name

OSGIN1

Target Full Name

Oxidative stress-induced growth inhibitor 1

Target Function

Regulates the differentiation and proliferation through the regulation of cell death.

Target Protein Families

OKL38 family

Target Tissue Specificity

Ubiquitous. Highest expression in the ovary, testis, kidney, skeletal muscle and liver. Weakly expressed in spleen, heart, kidney, and pancreas. Highly expressed in tumor cells (at protein level).

Target Synonyms

OSGIN1; BDGI; OKL38; Oxidative stress-induced growth inhibitor 1; Bone marrow stromal cell-derived growth inhibitor; BMSC-derived growth inhibitor; Ovary; kidney and liver protein 38; huOKL38; Pregnancy-induced growth inhibitor OKL38

Target Background

This gene encodes an oxidative stress response protein that regulates cell death. Expression of the gene is regulated by p53 and is induced by DNA damage. The protein regulates apoptosis by inducing cytochrome c release from mitochondria. It also appears to be a key regulator of both inflammatory and anti-inflammatory molecules. The loss of this protein correlates with uncontrolled cell growth and tumor formation. Naturally occurring read-through transcription exists between this gene and the neighboring upstream malonyl-CoA decarboxylase (MLYCD) gene, but the read-through transcripts are unlikely to produce a protein product.