Recombinant Human Pancreatic lipase-related protein 2 (PNLIPRP2)

Uniprot Id

P54317

Target Species

Human

Target Name

PNLIPRP2

Target Full Name

Pancreatic lipase-related protein 2

Target Function

Lipase that primarily hydrolyzes triglycerides and galactosylglycerides. In neonates, may play a major role in pancreatic digestion of dietary fats such as milk fat globules enriched in long-chain triglycerides. Hydrolyzes short-, medium- and long-chain fatty acyls in triglycerides without apparent positional specificity. Can completely deacylate triacylglycerols. When the liver matures and bile salt synthesis increases, likely functions mainly as a galactolipase and monoacylglycerol lipase. Hydrolyzes monogalactosyldiglycerols (MGDG) and digalactosyldiacylglycerols (DGDG) present in a plant-based diet, releasing long-chain polyunsaturated fatty acids. Hydrolyzes medium- and long-chain fatty acyls in galactolipids. May act together with LIPF to hydrolyze partially digested triglycerides. Hydrolyzes long-chain monoglycerides with high efficiency. In cytotoxic T cells, contributes to perforin-dependent cell lysis, but is unlikely to mediate direct cytotoxicity. Also has low phospholipase activity. In neurons, required for the localization of the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) to neurite tips through acyl chain remodeling of membrane phospholipids. The resulting OPPC-rich lipid membrane domain recruits the t-SNARE protein STX4 by selectively interacting with the STX4 transmembrane domain and this promotes surface expression of the dopamine transporter SLC6A3/DAT at neurite tips by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane.

Target Subcellular Location

Secreted. Zymogen granule membrane; Peripheral membrane protein. Cell projection, neuron projection.

Target Protein Families

AB hydrolase superfamily, Lipase family

Target Tissue Specificity

Pancreas.

Target Synonyms

EC 3.1.1.3; Galactolipase; LIPR2_HUMAN; Pancreatic lipase-related protein 2; PL-RP2; PLRP2; Pnliprp2; Secretory glycoprotein GP 3

Target Background

This gene encodes a lipase that hydrolyzes galactolipids, the main components of plant membrane lipids. An allelic polymorphism in this gene results in both coding and non-coding variants; the reference genome represents the non-coding allele.