Recombinant Human Pancreatic secretory granule membrane major glycoprotein GP2 (GP2)

Uniprot Id

P55259

Target Species

Human

Target Name

GP2

Target Full Name

Pancreatic secretory granule membrane major glycoprotein GP2

Target Function

Functions as an intestinal M-cells transcytotic receptor specific of type-I-piliated bacteria that participate in the mucosal immune response toward these bacteria. At the apical membrane of M-cells binds fimH, a protein of the bacteria type I pilus tip. Internalizes bound bacteria, like E.coli and S.typhimurium, from the lumen of the intestine and delivers them, through M-cells, to the underlying organized lymphoid follicles where they are captured by antigen-presenting dendritic cells to ellicit a mucosal immune response.

Target Subcellular Location

Zymogen granule membrane; Lipid-anchor, GPI-anchor. Secreted. Cell membrane; Lipid-anchor, GPI-anchor. Apical cell membrane; Lipid-anchor, GPI-anchor. Membrane raft; Lipid-anchor, GPI-anchor. Endosome.

Target Tissue Specificity

Expressed in pancreas (at protein level). Specifically expressed by M (microfold) cells which are atypical epithelial cells of the intestine (at protein level).

Target Synonyms

DKFZp779K0533; Glycoprotein 2 (zymogen granule membrane); GP2; GP2_HUMAN; Pancreatic secretory granule membrane major glycoprotein GP2; Pancreatic zymogen granule membrane associated protein GP2; Pancreatic zymogen granule membrane protein GP-2; ZAP75