Recombinant Human PAXIP1-associated protein 1 (PA1)

Uniprot Id

Q9BTK6

Target Species

Human

Target Name

PAGR1

Target Full Name

PAXIP1-associated glutamate-rich protein 1

Target Function

Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex. However, its function in DNA damage has been questioned. During immunoglobulin class switching in activated B-cells is involved in transcription regulation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus independently of the MLL2/MLL3 complex. Involved in both estrogen receptor-regulated gene transcription and estrogen-stimulated G1/S cell-cycle transition. Acts as transcriptional cofactor for nuclear hormone receptors. Inhibits the induction properties of several steroid receptors such as NR3C1, AR and PPARG; the mechanism of inhibition appears to be gene-dependent

Target Subcellular Location

Nucleus.

Target Tissue Specificity

Ubiquitously expressed.

Target Synonyms

C16orf53; Chromosome 16 open reading frame 53; FLJ22459; GAS; Glutamate rich coactivator interacting with SRC1/NCOA1; MGC4606; Pa1; PA1_HUMAN; PAXIP1 associated protein 1; PAXIP1-associated protein 1; PTIP associated 1 protein; PTIP associated protein 1; PTIP-associated protein 1