Recombinant Human Perforin-1 (PRF1)

Discover our Recombinant Human PRF1, a vital research tool for scientists exploring the functions and implications of Perforin-1 in immunology. This protein, also known as P1, Cytolysin, and Lymphocyte pore-forming protein, plays a crucial role in the immune system by facilitating the release of cytotoxic granules from cytotoxic T lymphocytes and natural killer cells, leading to the destruction of targeted cells. Our Recombinant Human PRF1 is the full length of mature protein (22-555aa), expressed in E. coli to ensure a consistent and reliable source for your research requirements. The protein features an N-terminal 6xHis-SUMO tag, enabling easy purification and detection. With a purity greater than 90% as determined by SDS-PAGE and available in both liquid and lyophilized powder forms, this high-quality recombinant protein provides the accuracy and performance necessary for your immunology research.

ACP04238

Discover our Recombinant Human PRF1, a vital research tool for scientists exploring the functions and implications of Perforin-1 in immunology. This protein, also known as P1, Cytolysin, and Lymphocyte pore-forming protein, plays a crucial role in the immune system by facilitating the release of cytotoxic granules from cytotoxic T lymphocytes and natural killer cells, leading to the destruction of targeted cells.
Our Recombinant Human PRF1 is the full length of mature protein (22-555aa), expressed in E. coli to ensure a consistent and reliable source for your research requirements. The protein features an N-terminal 6xHis-SUMO tag, enabling easy purification and detection. With a purity greater than 90% as determined by SDS-PAGE and available in both liquid and lyophilized powder forms, this high-quality recombinant protein provides the accuracy and performance necessary for your immunology research.

Number

Cat.No	ACP04238	Target Name	Prf1
Form	Liquid or Lyophilized powder	Expression System	E.coli
Expression Range	22-555aa	Mol Weight	75.2kDa
Protein Length	Full Length of Mature Protein	Purity	Greater than 90% as determined by SDS-PAGE.
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP04238

Target Name

Prf1

Form

Liquid or Lyophilized powder

Expression System

E.coli

Expression Range

22-555aa

Mol Weight

75.2kDa

Protein Length

Full Length of Mature Protein

Purity

Greater than 90% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	P14222

Background Information

Uniprot Id

P14222
Target Species

Human
Target Name

PRF1
Target Full Name

Perforin-1
Target Function

Pore-forming protein that plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes.
Target Involvement

Familial hemophagocytic lymphohistiocytosis 2 (FHL2)
Target Subcellular Location

Cytolytic granule. Secreted. Cell membrane; Multi-pass membrane protein. Endosome lumen.
Target Protein Families

Complement C6/C7/C8/C9 family
Target Research Area

Immunology
Target Synonyms

Cytolysin; FLH2; HPLH2; Lymphocyte pore-forming protein; P1; PERF_HUMAN; perforin 1 (pore forming protein); Perforin 1; Perforin-1; PFP; PGFL; PIGF; PIGF-2; PLGF; Pore forming protein; prf1; SHGC-10760
Target Background

This gene encodes a protein with structural similarities to complement component C9 that is important in immunity. This protein forms membrane pores that allow the release of granzymes and subsequent cytolysis of target cells. Whether pore formation occurs in the plasma membrane of target cells or in an endosomal membrane inside target cells is subject to debate. Mutations in this gene are associated with a variety of human disease including diabetes, multiple sclerosis, lymphomas, autoimmune lymphoproliferative syndrome (ALPS), aplastic anemia, and familial hemophagocytic lymphohistiocytosis type 2 (FHL2), a rare and lethal autosomal recessive disorder of early childhood.

Recombinant Human Perforin-1 (PRF1)

Specifications

Immunogen Information

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