Recombinant Human Peroxisomal acyl-coenzyme A oxidase 3 (ACOX3)

Uniprot Id

O15254

Target Species

Human

Target Name

ACOX3

Target Full Name

Peroxisomal acyl-coenzyme A oxidase 3

Target Function

Oxidizes the CoA-esters of 2-methyl-branched fatty acids.

Target Subcellular Location

Peroxisome.

Target Protein Families

Acyl-CoA oxidase family

Target Synonyms

ACOX3; BRCOX; PRCOXPeroxisomal acyl-coenzyme A oxidase 3; EC 1.3.3.6; Branched-chain acyl-CoA oxidase; BRCACox; Pristanoyl-CoA oxidase

Target Background

Acyl-Coenzyme A oxidase 3 also know as pristanoyl -CoA oxidase (ACOX3)is involved in the desaturation of 2-methyl branched fatty acids in peroxisomes. Unlike the rat homolog, the human gene is expressed in very low amounts in liver such that its mRNA was undetectable by routine Northern-blot analysis or its product by immunoblotting or by enzyme activity measurements. However the human cDNA encoding a 700 amino acid protein with a peroxisomal targeting C-terminal tripeptide S-K-L was isolated and is thought to be expressed under special conditions such as specific developmental stages or in a tissue specific manner in tissues that have not yet been examined.