Recombinant Human Peroxisomal carnitine O-octanoyltransferase (CROT)

Uniprot Id

Q9UKG9

Target Species

Human

Target Name

CROT

Target Full Name

Peroxisomal carnitine O-octanoyltransferase

Target Function

Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate. Converts the end product of pristanic acid beta oxidation, 4,8-dimethylnonanoyl-CoA, to its corresponding carnitine ester.

Target Subcellular Location

Peroxisome.

Target Protein Families

Carnitine/choline acetyltransferase family

Target Research Area

Tags & Cell Markers

Target Synonyms

Carnitine O octanoyltransferase; COT; CROT; OCTC_HUMAN; Peroxisomal carnitine acyltransferase; Peroxisomal carnitine O octanoyltransferase; Peroxisomal carnitine O-octanoyltransferase

Target Background

This gene encodes a member of the carnitine/choline acetyltransferase family. The encoded protein converts 4, 8-dimethylnonanoyl-CoA to its corresponding carnitine ester. This transesterification occurs in the peroxisome and is necessary for transport of medium- and long- chain acyl-CoA molecules out of the peroxisome to the cytosol and mitochondria. The protein thus plays a role in lipid metabolism and fatty acid beta-oxidation. Alternatively spliced transcript variants have been described.