Recombinant Human Pescadillo homolog (PES1)

Uniprot Id

O00541

Target Species

Human

Target Name

PES1

Target Full Name

Pescadillo homolog

Target Function

Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.

Target Subcellular Location

Nucleus, nucleolus. Nucleus, nucleoplasm. Chromosome.

Target Protein Families

Pescadillo family

Target Tissue Specificity

Significant levels are detected in a variety of cancer cell lines, including glioblastoma, breast carcinoma, colon carcinoma and cervical carcinoma cells. Levels are abnormally elevated in malignant tumors of astrocytic origin.

Target Research Area

Cancer

Target Synonyms

FLJ43790; Homo sapiens pescadillo mRNA complete cds; PES; PES 1; pes1; PESC_HUMAN; Pescadillo (zebrafish) homolog 1 containing BRCT domain; Pescadillo homolog 1; Pescadillo homolog 1 containing BRCT domain (zebrafish); Pescadillo homolog; Pescadillo ribosomal biogenesis factor 1

Target Background

This gene encodes a nuclear protein that contains a breast cancer associated gene 1 (BRCA1) C-terminal interaction domain. The encoded protein interacts with BOP1 and WDR12 to form the PeBoW complex, which plays a critical role in cell proliferation via pre-rRNA processing and 60S ribosomal subunit maturation. Expression of this gene may play an important role in breast cancer proliferation and tumorigenicity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the long arm of chromosome 4 and the short arm of chromosome 9.