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| Cat.No | ACP19146 | Target Name | PHACTR1 |
|---|---|---|---|
| Target Synonyms | PHACTR1; KIAA1733; RPEL1; Phosphatase and actin regulator 1 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-580 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9C0D0 |
|---|
Uniprot Id
Q9C0D0
Target Species
Human
Target Name
PHACTR1
Target Full Name
Phosphatase and actin regulator 1
Target Function
Binds actin monomers (G actin) and plays a role in multiple processes including the regulation of actin cytoskeleton dynamics, actin stress fibers formation, cell motility and survival, formation of tubules by endothelial cells, and regulation of PPP1CA activity. Involved in the regulation of cortical neuron migration and dendrite arborization.
Target Subcellular Location
Cytoplasm. Cell junction, synapse. Nucleus.
Target Protein Families
Phosphatase and actin regulator family
Target Tissue Specificity
Detected in umbilical vein endothelial cells.
Target Synonyms
PHACTR1; KIAA1733; RPEL1; Phosphatase and actin regulator 1
Target Background
The protein encoded by this gene is a member of the phosphatase and actin regulator family of proteins. This family member can bind actin and regulate the reorganization of the actin cytoskeleton. It plays a role in tubule formation and in endothelial cell survival. Polymorphisms in this gene are associated with susceptibility to myocardial infarction, coronary artery disease and cervical artery dissection. Alternative splicing of this gene results in multiple transcript variants.
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