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Recombinant Human Phosphate-regulating neutral endopeptidase (PHEX), Truncated

ACP06592

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Specifications

Cat.No	ACP06592	Target Name	PHEX
Target Synonyms	PHEX; PEX; Phosphate-regulating neutral endopeptidase PHEX; Metalloendopeptidase homolog PEX; Vitamin D-resistant hypophosphatemic rickets protein; X-linked hypophosphatemia protein; HYP	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Protein Length	Partial
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	P78562

Background Information

Uniprot Id

P78562
Target Species

Human
Target Name

PHEX
Target Full Name

Phosphate-regulating neutral endopeptidase PHEX
Target Function

Peptidase that cleaves SIBLING (small integrin-binding ligand, N-linked glycoprotein)-derived ASARM peptides, thus regulating their biological activity. Cleaves ASARM peptides between Ser and Glu or Asp residues. Regulates osteogenic cell differentiation and bone mineralization through the cleavage of the MEPE-derived ASARM peptide. Promotes dentin mineralization and renal phosphate reabsorption by cleaving DMP1- and MEPE-derived ASARM peptides. Inhibits the cleavage of MEPE by CTSB/cathepsin B thus preventing MEPE degradation.
Target Involvement

Hypophosphatemic rickets, X-linked dominant (XLHR)
Target Subcellular Location

Cell membrane; Single-pass type II membrane protein.
Target Protein Families

Peptidase M13 family
Target Tissue Specificity

Specifically expressed in ovary. Expressed at low levels in kidney.
Target Synonyms

PHEX; PEX; Phosphate-regulating neutral endopeptidase PHEX; Metalloendopeptidase homolog PEX; Vitamin D-resistant hypophosphatemic rickets protein; X-linked hypophosphatemia protein; HYP

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Recombinant Human Phosphate-regulating neutral endopeptidase (PHEX), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human Phosphate-regulating neutral endopeptidase (PHEX), Truncated Now

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