Recombinant Human PIH1 domain-containing protein 1 (PIH1D1)

Uniprot Id

Q9NWS0

Target Species

Human

Target Name

PIH1D1

Target Full Name

PIH1 domain-containing protein 1

Target Function

Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles. Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription. Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1. Positively regulates the assembly and activity of the mTORC1 complex.

Target Subcellular Location

Nucleus.

Target Protein Families

PIH1 family

Target Tissue Specificity

Expressed at low levels in normal mammary epithelial cells (at protein level). Highest expression in lung, leukocyte and placenta. Expressed at lower levels in brain, prostate, colon, heart, small intestine, liver, ovary, pancreas, skeletal muscle, spleen

Target Synonyms

NOP17; Nucleolar protein 17 homolog; PIH1 domain containing 1; PIH1 domain containing protein 1; PIH1 domain-containing protein 1; PIH1D1; PIHD1_HUMAN

Target Background

Enables several functions, including RNA polymerase I core promoter sequence-specific DNA binding activity; enzyme binding activity; and phosphoprotein binding activity. Involved in several processes, including box C/D snoRNP assembly; positive regulation of signal transduction; and regulation of cellular protein metabolic process. Located in cytoplasm and nucleolus. Part of R2TP complex and pre-snoRNP complex.