Recombinant Human Plasma alpha-L-fucosidase (FUCA2), Truncated

The expression region of this recombinant Human FUCA2 covers amino acids 29-465. The theoretical molecular weight of the FUCA2 protein is 77.7 kDa. This protein is generated in a e.coli-based system. The N-terminal GST tag was fused into the coding gene segment of FUCA2, making it easier to detect and purify the FUCA2 recombinant protein in the later stages of expression and purification.Human plasma alpha-L-fucosidase, encoded by the FUCA2 gene, is an enzyme involved in the hydrolysis of alpha-L-fucosidic linkages in various glycoconjugates. This lysosomal enzyme plays a crucial role in the degradation of complex carbohydrates, including glycoproteins and glycolipids containing terminal fucose residues, contributing to cellular homeostasis. Deficiencies in human FUCA2 are associated with fucosidosis, a lysosomal storage disorder characterized by the accumulation of fucose-containing substances. The study of FUCA2 contributes to understanding lysosomal function, glycoprotein metabolism, and the pathological mechanisms underlying fucosidosis, providing insights into potential therapeutic strategies for lysosomal storage disorders.