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Recombinant Human Pleckstrin homology domain-containing family N member 1 (PLEKHN1)

ACP17455

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Specifications

Cat.No	ACP17455	Target Name	PLEKHN1
Target Synonyms	PLEKHN1; CLPABP; Pleckstrin homology domain-containing family N member 1; PH domain-containing family N member 1; Cardiolipin and phosphatidic acid-binding protein	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	1-663
Protein Length	Full length protein	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q494U1

Background Information

Uniprot Id

Q494U1
Target Species

Human
Target Name

PLEKHN1
Target Full Name

Pleckstrin homology domain-containing family N member 1
Target Function

Controls the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR, in cooperation with the RNA stabilizer ELAVL1. Decreases the stability of the leptin mRNA by antagonizing the function of ELAVL1 by inducing its atypical recruitment from the nucleus to the cytosol. Binds to cardiolipin (CL), phosphatidic acid (PA), phosphatidylinositol 4-phosphate (PtdIns(4)P) and phosphatidylserine (PS). Promotes apoptosis by enhancing BAX-BAK hetero-oligomerization via interaction with BID in colon cancer cells.
Target Subcellular Location

Cell membrane; Lipid-anchor. Mitochondrion. Mitochondrion membrane.
Target Tissue Specificity

Ubiquitous. Epressed in several cancer cell lines of differing origin.
Target Synonyms

PLEKHN1; CLPABP; Pleckstrin homology domain-containing family N member 1; PH domain-containing family N member 1; Cardiolipin and phosphatidic acid-binding protein

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Recombinant Human Pleckstrin homology domain-containing family N member 1 (PLEKHN1)

Specifications

Immunogen Information

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