Recombinant Human POC1 centriolar protein homolog B (POC1B)

Uniprot Id

Q8TC44

Target Species

Human

Target Name

POC1B

Target Full Name

POC1 centriolar protein homolog B

Target Function

Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Acts in concert with POC1A to ensure centriole integrity and proper mitotic spindle formation. Required for primary cilia formation, ciliary length and also cell proliferation. Required for retinal integrity.

Target Involvement

Cone-rod dystrophy 20 (CORD20)

Target Subcellular Location

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, spindle pole.

Target Protein Families

WD repeat POC1 family

Target Tissue Specificity

Expressed in the retina.

Target Synonyms

4933430F16Rik; FLJ14923; FLJ41111; Pix1; POC1 centriolar protein homolog B (Chlamydomonas); POC1 centriolar protein homolog B; POC1B; POC1B_HUMAN; TUWD12; WD repeat containing protein 51B; WD repeat domain 51B; WD repeat-containing protein 51B; WDR51B

Target Background

POC1 proteins contain an N-terminal WD40 domain and a C-terminal coiled coil domain and are part of centrosomes. They play an important role in basal body and cilia formation. This gene encodes one of the two POC1 proteins found in humans. Mutation in this gene result in autosomal-recessive cone-rod dystrophy. Alternative splicing results in multiple transcript variants.