Recombinant Human Polycomb group RING finger protein 6 (PCGF6)

Uniprot Id

Q9BYE7

Target Species

Human

Target Name

PCGF6

Target Full Name

Polycomb group RING finger protein 6

Target Function

Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity.

Target Subcellular Location

Nucleus.

Target Tissue Specificity

Ubiquitous.

Target Synonyms

MBLR; Mel18 and Bmi1 like RING finger protein; Mel18 and Bmi1-like RING finger; Pcgf6; PCGF6_HUMAN; Polycomb group RING finger protein 6; RING finger protein 134; RNF134

Target Background

The protein encoded by this gene contains a RING finger motif, which is most closely related to those of polycomb group (PcG) proteins RNF110/MEL-18 and BMI1. PcG proteins are known to form protein complexes and function as transcription repressors. This protein has been shown to interact with some PcG proteins and act as a transcription repressor. The activity of this protein is found to be regulated by cell cycle dependent phosphorylation. Alternatively spliced transcript variants encoding different isoforms have been identified.