Recombinant Human Potassium voltage-gated channel subfamily A member 6 (KCNA6), Truncated

Uniprot Id

P17658

Target Species

Human

Target Name

KCNA6

Target Full Name

Potassium voltage-gated channel subfamily A member 6

Target Function

Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA6, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel. Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation. Homotetrameric channels display rapid activation and slow inactivation.

Target Subcellular Location

Cell membrane; Multi-pass membrane protein.

Target Protein Families

Potassium channel family, A (Shaker) (TC 1.A.1.2) subfamily, Kv1.6/KCNA6 sub-subfamily

Target Synonyms

KCNA6; Potassium voltage-gated channel subfamily A member 6; Voltage-gated potassium channel HBK2; Voltage-gated potassium channel subunit Kv1.6