Recombinant Human Potential tRNA (adenine (58)-N (1))-methyltransferase catalytic subunit TRMT61B (TRMT61B)

Uniprot Id

Q9BVS5

Target Species

Human

Target Name

TRMT61B

Target Full Name

tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial

Target Function

Methyltransferase that catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in various tRNAs in mitochondrion, including tRNA(Leu) (deciphering codons UUA or UUG), tRNA(Lys) and tRNA(Ser) (deciphering codons UCA, UCU, UCG or UCC). Catalyzes the formation of 1-methyladenosine at position 947 of mitochondrial 16S ribosomal RNA and this modification is most likely important for mitoribosomal structure and function. In addition to tRNA N(1)-methyltransferase activity, also acts as a mRNA N(1)-methyltransferase by mediating methylation of adenosine residues at the N(1) position of MT-ND5 mRNA, leading to interfere with mitochondrial translation

Target Subcellular Location

Mitochondrion.

Target Protein Families

Class I-like SAM-binding methyltransferase superfamily, TRM61 family

Target Synonyms

TRMT61B; tRNA; adenine(58)-N(1))-methyltransferase; mitochondrial; EC 2.1.1.220; mRNA methyladenosine-N(1)-methyltransferase; EC 2.1.1.-

Target Background

Enables mRNA (adenine-N1-)-methyltransferase activity; rRNA (adenine) methyltransferase activity; and tRNA (adenine-N1-)-methyltransferase activity. Involved in mRNA methylation; mitochondrial tRNA methylation; and protein homooligomerization. Located in mitochondrion.